These calculations support the view that the origin of replication and metabolism together is plausible.

When replicated, there are as many as one thousand origins of replication.

The missing link for this class of theories is still the origin of replication.

An origin of replication opens, and the heavy strand is replicated in one direction.

Replisome assembly at an origin of replication is roughly divided into three phases.

E2 facilitates the binding of E1 to the viral origin of replication.

- a free, open source program for predicting "origins of replication" using Z-curves.

There are also significant differences between prokaryotic and eukaryotic origins of replication:

Viruses often possess a single origin of replication.

Eukaryotes typically have multiple origins of replication; at least one per chromosome.