Feeling and awareness came back gradually, even pain took its time.

As she became a part of him, her pain and anger took effect.

Low back pain can take its toll on your mental health.

By the time she'd left Virginia, the anger and the pain had taken them past the point of his asking her not to go.

The pain of having doubted her took him to his knees.

He took a deep breath, letting the pain take him.

A deep pain took hold of her, and she knew she must love him.

It might be responded that the pain "takes place in the brain."

Though the pain was slowly taking its toll, he could handle it for a while.

The pain may be worse when you lie down or take a deep breath.