"May I ask if the problem has some personal significance?"

And how important is the face in this quest for personal significance or salvation?

They can also write their names and other words that have personal significance.

In terms of purely personal significance, you cannot get any deeper than that.

Each senior also presents a speech to the entire community on a topic of personal significance.

This last work may have held some personal significance for Veronese.

I am pleased that so many people are present today for whom the 9th of May has such a personal significance.

I assume it has a certain amount of personal significance now, though?

Aunt Anna's was the only one of great personal significance.

The reason for trying to lose weight should be a permanent one of personal significance.