Cleveland now leads the American League with 13 home runs, while Seattle's pitchers have surrendered a dozen homers, worst in the league.
The Cards' pitchers surrendered no runs until the seventh, and by then they were holding a 4-0 lead.
If the pitcher surrenders the lead at any point, he cannot get a save, even if his team comes back to win.
The Pirates take the lead when the Knights' starting pitcher, Fowler, surrenders a two-run homer.
But by touching the ball, even inadvertently, the pitcher surrendered his defense's chance to field the ball without interference by a runner.
Four pitchers, including presumed game four starter Jaret Wright, surrendered nine runs in relief.
Their pitchers have surrendered at least one home run in 12 consecutive games.
It was his first home run off his former Pittsburgh Pirate teammate, who became the 441st different pitcher to surrender a four-bagger to Bonds.
So their pitchers have surrendered 21 runs before their hitters have even lifted a bat out of the rack.
Along the way, six pitchers surrendered 13 hits and 10 walks, and Juan Samuel lost a fly ball with the bases loaded.