No placebo-controlled clinical studies exist so far to support aphrodisiac activity.
Large placebo-controlled studies of olanzapine and aripiprazole were underway in early 2008.
Two double-blind, placebo-controlled studies found no statistically significant effect on autistic behaviors, and reported few side effects.
This same side effect makes methylene blue difficult to test in traditional placebo-controlled clinical studies.
Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies.
A similar placebo-controlled study is now under way in women.
Such a test or clinical trial is called a placebo-controlled study.
As a result, "placebo-controlled studies often are designed in such a way that disadvantages the placebo condition".
Valproate in the treatment of acute mania: a placebo-controlled study.
"If you put this under a microscope in a double-blind, placebo-controlled study, it would be hard to say what helped her," he said.