A predictive marker is a particular protein or gene that indicates sensitivity or resistance to a specific therapy.

The use of predictive markers is becoming increasingly relevant in cancer therapy as it allows for better identification of patients who will respond positively to the therapy.

In the clinical setting, predictive markers are limited to use in breast cancer.

The presence of anti-Topo-I antibodies is associated with diffuse cutaneous involvement and pulmonary interstitial fibrosis [ 8] and is considered a predictive marker of diffuse SSc.

Pegram MD, Pauletti G, Slamon DJ: HER-2/neu as a predictive marker of response to breast cancer therapy.

Gene products of these paralogous genes contained a unique bi-lobed hydrophobic domain, which is a predictive marker for localization to the inclusion membrane [ 15 ] .

This is important, since in the early stages of RA, the synovium is primarily affected, and synovitis seems to be the best predictive marker of future joint damage.

The MIB-1 index is a predictive marker of malignant potential.

High ERCC1 is thus a negative predictive marker, referring to how it will respond to a specific type of treatment.

One example of the clinical application of pharmacometabolomics was a study that looked to identify a predictive metabolic marker for the treatment of major depressive disorder (MDD).