He felt a profound despair settle over him like a coat made of lead, rendering him unable to move.

He had visited the End of Time, and left it in the most profound despair.

A despair so profound that he lost all sense of his center overcame him.

He tried to resist the crush of desolation, giving in to his pain, but he had never known such profound despair.

At the same time, substantial segments of black society have fallen into a state of profound despair.

East Enders could hide the most profound despair in a heartbeat; it was their survival camouflage.

We never quite know what drives Elsa, other than a profound despair at the loss of Otto.

A profound despair filled Gideon as he put his arm around her shoulder.

Leta, passing me last, gave me a look of profound despair.

"He had never done a play, but he had great instincts, huge accessibility and could go very deeply from profound despair to extraordinary joy."