By age 2 or 3, autistic children display a profound lack of responsiveness to others.

On the disheartening side, there was a profound lack of personal items in the house.

It was, I knew, a jab at my profound lack of interest in fatherhood.

During the 1990's, this group demonstrated a profound lack of good judgment about long-term security.

Moreover, there is a profound lack of agreement on what the concept actually refers to.

Who demonstrated what you might call a profound lack of interest.

She tried to fight her way out, with profound lack of effect.

"This is all about a profound lack of respect for who we are and what we do."

The real problem on these beaches, and in this town, has long been the profound lack of respect for public, not private, property.

There can be a profound lack of integration between the past and the present since: