But it has profoundly altered the nation's political life as well.

All of us have to respond to a world that is profoundly altered.

The relationships between senior staff in health authorities has altered profoundly.

He had also profoundly altered the nature of the Byzantine government.

The death profoundly altered their lives, leaving within them a hole that can never be filled.

And in Chile, the case has profoundly altered the country's historical memory.

His work profoundly altered the economic life of Central American countries.

But, as Europe changes, we must profoundly alter the way we think about defense.

The current increase in greenhouse gases, he continued, is similar to past natural changes that profoundly altered the world.

The move could profoundly alter telecommunications in the United States.