At that time, she was described by Cassidy as 'profoundly depressed.'

She herself has been profoundly depressed and suicidal.

Personally I get profoundly depressed hearing about some celebrity's life imploding so visibly.

He states: "Psychotherapy is of little use to the profoundly depressed, and antidepressants are, to put it generously, unreliable.

During intermission, profoundly depressed, I bought a glass of wine in the lobby.

He is concerned with us, surely, but profoundly depressed.

"There was a profoundly depressed patient who had been there for seven years," he said.

Frank came into treatment profoundly depressed, believing that he was now absolutely worthless because he no longer had the money and power he had before.

The diaries offer an image of a profoundly depressed man, isolated from friends and family, involved in a series of failed relationships, and constantly sick.

In October, 2003, feeling "profoundly depressed," she left Washington and moved to a small town in Oregon.