Results showed that participants scoring high on hardiness had significantly higher mean antigen- and mitogen-induced proliferative responses.

The proliferative responses and potential for Th1 and Th2 phenotype development were therefore examined following adenoviral transduction.

CR-1409 completely abolished this proliferative response and also prevented the rise in nucleic acid and protein contents.

The increase in proliferative response became increasingly obvious at two weeks (1.43 v 0.20%) and was still present at three weeks (0.88 v 0.35%).

The surviving fraction of stem cells, which may be as low as 1/100000 mount a proliferative response.

The remaining T cells have poor proliferative and cytolytic responses and poor interleukin-2 production, although thymic development appears normal.

In order to be classified as an epitope, the average proliferative response to a peptide had to reach a stimulation index of 3.0.

Peptides eliciting a 3-fold or higher average proliferative response over the background response were considered T cell epitopes.

Any or all of these mechanisms could contribute to the enrichment for peptide-specific proliferative responses seen in vitro.

A proliferative response was counted as positive if the average counts for a particular peptide were three times higher than the control levels.