Buffalo tailback Aaron Leeper raced 21 yards untouched for a second-quarter touchdown, capping an 80-yard drive and giving the Bulls the lead for good.
After taking his first carry from scrimmage against the University of Arkansas in 2002, Williams raced untouched 80 yards to the end zone.
But Patterson stepped in front of the Los Angeles wide receiver, picked it off and raced untouched for the winning score.
With eight minutes left in the half, Johnson took an option pitch from Mills, raced untouched for 20 yards, then cut back against the grain for a 78-yard score.
Tellison caught the ball at Virginia Tech's 30-yard line and raced untouched into the end zone to complete a 45-yard play.
But Lewis picked off a pass by Tommy Maddox intended for Reggie Moore and raced untouched down the left sideline for the winning score.
Hurst, a rookie drafted on the fourth round, stepped in front of the intended receiver, James Lofton, caught the ball and raced untouched for his first pro touchdown.
He raced untouched into the end zone with 4:46 left in the third period for a 24-10 lead for the Tigers (3-1, 1-0).
Safety Shawn Seabrooks intercepted a pass by Buffalo's Joe Freedy and raced untouched down the sideline for a 73-yard touchdown.
Toresco turned and pitched the ball to Terrell, who raced untouched around right end for a touchdown.