Availability was severely limited, however, by the difficulty of manufacturing large quantities of penicillin and by the rapid renal clearance of the drug, necessitating frequent dosing.

This rapid clearance can be an advantage in applications such as in vivo diagnostic imaging.

Taken together, these findings show mephedrone induces a massive increase in both DA and 5-HT, combined with rapid clearance.

The bill thus needs rapid clearance by the Senate Finance Committee and the House Ways and Means Committee when Congress returns after Labor Day.

However due to a rapid metabolic clearance analogs of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance.

In contrast to the rapid clearance of Parecoxib, plasma concentration of Valdecoxib declines slowly because of a longer half-life.

The exposure of the subterminal galactose residues results in rapid clearance of the glycoproteins from the circulation through hepatocyte asialoglycoprotein receptors on Kuppfer cells.

Perhaps the most perplexing effect of IL-2 administration is a rapid (within 1 hour) and paradoxical clearance of monocytes and lymphocytes from the peripheral blood (Figure 1a).

To limit radiation exposure, murine antibodies were especially chosen, as their high immunogenicity promotes rapid clearance from the body.

This is likely due to venlafaxine's relatively short half-life and therefore rapid clearance upon discontinuation.