A G-protein-coupled receptor (GPCR) then appears to be ligated.
Other nuclear receptors, such as CAR and PXR appear to function as xenobiotic sensors up-regulating the expression of cytochrome P450 enzymes that metabolize these xenobiotics.
That receptor appears as part of the body's response to infection by some other germ like a cold virus or some other irritation like breathing in smoke, Dr. Tuomanen said.
In general the mechanisms of desensitization for the alpha-2 adrenergic receptors appear to be similar to those for the beta-2 receptor.
While receptor, cell, and tissue-specific differences almost certainly exist and appear to make any single mechanism of ERK activation unlikely, certain generalities have begun to emerge.
These receptors are involved in presynaptic inhibition, and do not appear to affect postsynaptic membrane potential by themselves.
However, even in transgenic animal models overexpressing alpha receptors, the beta-adrenergic receptor appears to play an important role in hypertrophy development and the transition to heart failure [ 34 35 ] .
The receptor for the PfRh5 protein appears to be the Ok blood group antigen, basigin.
Specifically in diabetic mice, the κ-opioid receptor appears to be involved in the antinociceptive effects of oxycodone, while in nondiabetic mice, the μ-opioid receptor seems to be primarily responsible for these effects.
Company officials said the particular receptors covered by the patent, known as 1D Alpha and 1D Beta, appear to be involved in many disorders and are being investigated by companies around the world.