Different studies have been done to propose alternative tools to the reference method of detection, (classical microscopy).
The most popular of these reference methods is certainly persistence.
Nevertheless it is not a "gold standard" or reference method.
It is generally accepted that the full reference (FR) method provides the best accuracy for perceptual picture quality measurements.
We may take samples of wine which will be analysed using the reference method described in section 26.
It is this nonspecificity that has motivated the development of new reference methods for creatinine analysis into the 21st century.
Fuller's earth was also used for protein-binding, but the reference method until the 1980s was adsorption with Lloyd's reagent.
Kt/V is one of the reference methods by which the amount of dialysis given is measured.
To a certain extent this involves determining uniform European analytical methods which we can therefore regard as reference methods.
Deviation(s) from reference method, if any, and the reason(s) 4.