In addition to this, treatment usually requires high dosages.
Originally, it was believed that injections would be more effective, thus requiring far smaller dosages than with oral administration.
In February 1935 another patient named Mrs Kemp died from an illness which required large dosages of morphine.
And this is where he runs into difficulty with the anti-doping agencies, which require exact dosages on therapeutic exemption forms.
Patients with slow clearance of the drug (via acetylation as described above) may require reduced dosages to avoid toxicity.
Another reason for drug holidays is to permit a drug to regain effectiveness after a period of continuous use, and to reduce the tolerance effect that may require increased dosages.
Congressman Seeks Review And Representative John D. Dingell, Democrat of Michigan, has challenged the safety and effectiveness of generic drugs used to treat epilepsy and other conditions that require exact dosages.
If it is, do these medicines require different dosages?
Different brands or formulations may require different dosages.