This torsional freedom could be used by the ITU derivate to bind to a mutated NNIBP and thus compensating for the effects of a resistance mutation.

Sequential application of drugs can lead to the sequential evolution of resistance mutations to each drug in turn.

All kinases share some common features, and a resistance mutation very similar to the one identified here has also been found in other kinase genes from tumors with acquired resistance to imatinib, another kinase inhibitor.

The virus developed the three expected resistance mutations and became inactive.

A greater number of resistance mutations was detected in the repeated interruption arm, as summarized in Table 3.

Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.

The most commonly encountered resistance mutations are M204V/I/S.

Other resistance mutations are L80V/I, V173L and L180M.

Intriguing in-vitro studies also suggest that introduction of resistance mutations to one antiretroviral compound (didanosine) can diminish previously documented resistance to another agent (zidovudine).

The results of the 2005 study indicated that the virus was unable to gain resistance mutations during the blips, and that many of the blips could be attributed to statistical artifact.