Depression causes you to feel sad and hopeless much of the time.

At heart, Kitty is a good woman, but she's not well and, saddest of all, she knows it.

It's very sad, of course, but you mustn't think too much about it.

The following days were the saddest of any that the colonists had passed on the island!

What a sad mishandling of the political situation that would be.

We were all so sad, all of us but one.

Saddest of all are the few old men who hang out there.

He was the youngest, the most sweetly sad of the three.

She gets very sad of course and cries heart breakingly.

Depression is an illness that makes a person feel sad and hopeless much of the time.