"Because you've been late three times, and it's really screwed up my life every time, you know?"

I can see how screwed up my life has been, staying with him.

"To screw up your life with drugs makes no sense."

"I just hate to see you screw up your life like this."

The only thing I have a problem with is how the media attention screwed up your life.

The Army's already done enough to screw up my life, thanks very much.

There was nothing like the return of an old love for screwing up your life.

Nor had it stopped him from nearly screwing up her life.

In one sentence I'd basically screwed his life up beyond repair.

I don't know how you screwed up his life.