Cinnarizine has also been found to be a valuable second-line treatment for idiopathic urticarial vasculitis.

Triclofos is a sedative drug used rarely for treating insomnia, usually as a second-line treatment after other drugs have failed.

A specific exemption to that ban allows it to continue to be used as a second-line pharmaceutical treatment for lice and scabies.

It has also been used to great effect as a second-line treatment for Capnocytophaga infections.

It is not as commonly used today, but is sometimes used to treat major depression as a second-line treatment.

It is approved in the United States for use as a second-line treatment.

Due to more widespread experience, it is only used as a second-line treatment if lactulose is not effective or poorly tolerated.

Inhaled glucocorticoids are the second-line treatment for asthma.

But second-line treatments can have an easier time winning approval.

An experimental, but effective second-line treatment for chronic infections, is the use of boric acid.