In the early 1990s it was hypothesized that selenium deficiency in the soils of the coastal plain might be a causative factor.

Preventing lower than normal levels of selenium (selenium deficiency).

Excess iodine can be more cytotoxic in the presence of selenium deficiency.

Thiocyanate overload in Central Africa, especially if also in conjunction with selenium deficiency.

This might decrease the normal activity of selenium, possibly resulting in symptoms of selenium deficiency.

The effect of selenium deficiency on health remains uncertain, particularly in relation to Kashin-Beck disease.

There is an epidemiological association between selenium deficiency and prostate cancer.

(A selenium deficiency is believed to play a role in psoriasis and other skin conditions.)

Among healthy people in the U.S., selenium deficiencies are uncommon.

To improve nutrition, this grand challenge focuses on iron, zinc, and selenium deficiencies.