With George Church he developed the first direct genomic sequencing method in 1984.
The new sequencing methods are quite similar in approach.
Work proceeded slowly at first, but accelerated as new sequencing methods were developed in the 1970s and 1980s.
There are many new sequencing methods used in this sequencing step.
Each base in this sequencing method is read twice.
The cost per run is also significantly lower than that of alternative automated sequencing methods, at roughly $1,000.
The template is now ready to be prepared for the desired sequencing method.
Currently, the following sequencing methods are used, but the laboratory will be responsive to technological advances in the field.
Note that this is the opposite direction to polymerase based sequencing methods.
This sequencing method and equipment were used to sequence the genome of the M13 bacteriophage.