You start me on my investigation with a very serious handicap.

But what would we do if the triplets were born with serious handicaps?

One serious handicap kept the giants on the earth; they could not fly.

Living outside of Oxford would also be a serious handicap.

"Education is the key, and if you don't have that, then you're working with a truly serious handicap."

In a demonstration of this magnitude, it would be a serious handicap.

The son was born out of wedlock, a serious social handicap.

We also have a serious handicap in that we're down to two choppers.

The constant danger to life there is felt as a serious handicap which makes all healthy development impossible.

Lack of concentration is a serious handicap to a professional person, whether young or old.