Arguing from studies of first language development has serious limitations.

By contrast, volume for living space is not a serious limitation.

"The most serious limitation of these studies is the exposure assessment," they write.

By doing so he made sure that it was not a serious limitation on his freedom of action.

This method had serious limitations, though it was universally used.

As this cannot easily be enforced, it remains a serious limitation.

What they will find is a craft with serious limitations but hundreds of potential uses.

Not to mention the serious limitations of much educational and social science research.

Yet banking at the living room computer still has some serious limitations.

I would suspect it has serious limitations in both range and speed.