In an episode of metabolic decompensation, lactic acid levels abruptly rise and can exceed 15 mM, producing severe metabolic acidosis.

Manifestations of severe metabolic acidosis include vomiting and hyperpnea, which can exacerbate hypoglycemia by reducing oral intake.

Significantly, fourteen toxic seizures were recorded with two patients suffering life-threatening toxicity with status epilepticus and severe respiratory and metabolic acidosis.

The diagnosis is confirmed when the usual blood chemistries in the emergency department reveal hyperglycemia and severe metabolic acidosis.

When symptoms are present, they are variable, ranging from severe, neonatal acidosis to mild developmental delay with hypotonia.

The diagnosis of ethylene glycol poisoning should be considered in any patient with a severe acidosis.

Alternatively, patients presenting late with signs and symptoms of coma, hyperkalemia, seizures, or severe acidosis have a poor prognosis.

Acute haemolytic crises usually result from exposure to oxidant drugs, fava beans, bacterial or viral infections, or severe acidosis - for example, diabetic ketoacidosis.

But their effectiveness at normal consumption levels is unproven, while at least one case of severe acidosis caused by long-term consumption of such products has been documented.

In mice, anatoxin-a seriously also seriously impacted blood pressure and heart rate, and caused severe acidosis.