These occurrences have often led to severe toxicity or death in both children and adults.

However, because of the severe toxicity associated with the injection, L-Dopa was not of practical value as a treatment.

Even at this dosage, Gilenya can have severe toxicity.

Despite its severe toxicity, Muk has the ability to control its toxins and will never deliberately cause harm unless provoked to do so.

Flumequine was associated with severe ocular toxicity, which precluded its use in human patients.

A second 5 gm dose can be given in patients with severe toxicity.

Milder forms of the disease (type 2) do not cause severe toxicity, liver damage, or changes in thinking during childhood.

If severe toxicities develop to one drug, the dose is reduced or the patient is switched to another.

Common endpoints are severe toxicity, disease progression, or death.

However, individual responses may vary and people who have ingested similar amounts may develop anything from minimal to severe toxicity.