Far from being in its heyday, Constantinople was severely depopulated as a result of the general economic and territorial decline of the empire following its partial recovery from the disaster of the Fourth Crusade inflicted on it by the Christian army two centuries before.

It was severely depopulated and in 1872 the government of the newly formed German state abolished the city rights granted to Hel six centuries previously.

During that same period some areas of the country, such as the Apennines, have been severely depopulated.

At the time of the Turkish conquest it was severely depopulated, and had to be provided with new settlers, partly Albanians.

The Right Bank was severely depopulated, many of those who were not killed or enslaved by the Tatars having fled to the Left Bank or Sloboda Ukraine.

The Mocama Province was severely depopulated in the 17th century by infectious disease and warfare with other Indian tribes and the English colonies to the north.

Cyprus was severely depopulated and Jews banned from living there.

The inner-city districts were severely depopulated.

In the twentieth century, the area was severely depopulated and there are no residences or other buildings along the Barbersville Road for about two miles, including the area in which the town was once located.

The area was severely depopulated in the end of the 16th century and in the beginning of the 17th century, as a consequence of a series of epidemics followed by the Time of Troubles.