There have been no other significant alterations to the house since then.

No significant alterations have been made to the building since it opened in 1902.

The point is, what's happening represents a significant alteration to history.

There have been no other significant alterations to the house in the course of its existence.

There is a significant alteration about the contact between the two rocks.

There have been no significant alterations to the building other than those.

The house was built in 1878, but had significant later alterations.

There have been no significant alterations to the property since.

There have been no significant alterations to the exterior structure of the building.

That has been the only significant alteration to the building's exterior.