There are several surgical treatments, all carrying a risk of significant complications.

In addition, no significant medical complications were observed and/or treated by the athletic training staff during the study.

One of the significant complications of trastuzumab is its effect on the heart.

While these injuries are rare, significant complications can occur.

A significant complication to player's lives is caused by a limit of only 16 different ship designs per player.

Moreover, the procedure may lead to significant complications, including blindness in 1-2%.

The most significant long-term complication is related to the kidneys.

The review did not find evidence of increased significant complications.

I think most patients consider the significant complication to have hit their wallet, because they didn't get much for their money.

This method suffers from a number of significant complications compared to the others.