This lower limit has been a significant constraint in cosmology.

The Naʼvi language was developed under three significant constraints.

The Dothraki language was developed under two significant constraints.

Despite this significant constraint, Construction remarked that there was "not.

Fresh water has always been a significant constraint on any permanent settlement.

Poor services were not being shut down and "unacceptable" variations in quality of care could continued because so many hospitals faced significant financial constraints.

Nervousness about the future is also a significant constraint.

His lack of experience has been a significant constraint on his ability to move up in the company.

The shortage of human resources throughout the health sector is a significant constraint.

But there is little question that fear of aerial interdiction has been a significant constraint on Peruvian drug production.