Such schemes might abolish traffic jams once and for all, but they also have significant downsides.

But as scientists are coming to understand and the new guidelines were meant to reflect screening has a significant downside.

There are significant downsides, of course, and one is the interest that such mortgages engender.

That seems like it could be a pretty significant downside.

If it turns into a currency crisis, the market will have significant downside," with declines of 30 to 50 percent.

The times may be terrific, but American working families are not well-prepared for significant downside economic surprises.

A changing interest rate is another, possibly significant, downside.

But being a Yankee fan had a significant downside.

A significant downside to helicopters is that they cannot capture or hold objectives, which means they can only act as support.

But there is a significant downside to the treatment, which costs up to $8,000.