Limb loss can present significant or even drastic practical limitations.

However, the critical infrastructure supporting the system is facing significant limitations.

Although Version 1.0 was a major step forward, it had some significant limitations.

The study design and 24-h trial period impose significant limitations on the results.

If the coal plant was not built, there would have been significant limitations placed on industrial development in the country.

"There are significant limitations on what we can do because of limits under Federal laws," he explained.

Though useful, all of these measures have significant limitations when applied to pediatric patients.

"Natural language is, I think, going to have some significant limitations."

This meant of course that every leader had his or her significant limitations.

This is a particular challenge in areas with significant natural limitations.