A three-year study of nearly 900 women may result in a significant refinement in hormone replacement therapy after menopause.

A. Within the last year, we've made significant refinement in the way packages are tracked.

They further claim that film cameras have more flexibility and reliability in actual work conditions, and that motion picture film and cameras are capable of significant refinement beyond current levels.

Together with significant aerodynamic refinement, this led to much lower fuel consumption and therefore longer range, as well as lower operating costs.

Jo Ivey Boufford, president of the city's Health and Hospitals Corporation, of which E.M.S. is a division, said the agency had made "significant refinements" in its procurement policies in recent months.

Vista is not simply XP with a new skin; core parts of the OS have been radically overhauled, and virtually every area has seen significant refinement.

Despite this early success, the influence exploder, which would become the Mark VI, needed significant refinement.

The project was deemed interesting but in need of significant refinement.

Various scholars have offered significant refinements to this basic formulation (details below).

This is a significant refinement to the Rational Unified Process.