Therefore, a cat may have significant clinical signs long before the development of a positive test.

This is a significant sign of good relationship between two countries.

Since that time the coalition has seen significant signs of weakening.

A more significant sign was the 1998 Florida Governor's race.

"Indeed, we are already seeing significant signs of some reversals."

Even the main structure was showing significant signs of weakness.

This is a significant sign and may be due to fracking or other man made changes in the ground.

But it was the first significant sign that the vote could be going against American.

It is also a particularly significant sign in the current context.

This was seen as a significant sign of support for the democratic new beginning in Slovakia.