Consult a doctor if symptoms persist for more than two weeks or if they significantly impair your normal activities.

"How could we justify a transaction which could significantly impair our own capability?"

In 2008, the situation became critical because the global financial crisis and the related credit crunch significantly impaired the ability of consumers to purchase automobiles.

For some people, symptoms may cause severe nightly sleep disruption that can significantly impair a person's quality of life.

In almost all situations, accessible design can be used without significantly impairing the historic features of the facility.

Thus, this condition may significantly impair the person's functioning and even physical health.

Patients who have advanced cancer commonly experience chronicnausea and vomiting, which can significantly impair quality of life.

Chronic nausea can significantly impair a patient's quality of life.

While the aircraft performed well, its range significantly impaired it.

Generally, these are errors that significantly impair system function and business operations, increase the system's vulnerability, or both.