The voltage-gated sodium channels cause persistent sodium current into the cell, which generates the action potential.

Ranolazine is believed to have its effects via altering the transcellular late sodium current.

F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5 (Vacher et al.,.

Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.

These two effects increase the so-called window current, a measure for the non-inactivating fraction of the sodium currents, by 225%.

And we're now measuring the sodium current flowing through the membrane, here given in terms of nanoamps.

Furthermore, if you give a second pulse, a short period after the first pulse, you fail to elicit a large sodium current.

It is noteworthy that unmasking persistent sodium current in presence of Calcium channel blocker has been well established.

They are then able to engage voltage-gated calcium and sodium currents to fire bursts of action potentials.

In addition, in response to a slow, depolarizing stimulus, most mutant channels will generate a larger than normal sodium current.