Paul himself decides to go through the spice agony to test whether he may be the Kwisatz Haderach, and succeeds.

This was classical violence carried in many memories, which had come down to her in the moments of spice agony.

Baram had never been permitted to try the spice agony.

Until Paul Atreides, all men who had attempted the spice agony had died.

Jessica endured the spice agony while pregnant with her daughter, Alia.

So the spice agony will be denied him, but nothing else.

He thought suddenly that the spice agony must be like this for a Reverend Mother.

Was it akin to what a Reverend Mother experienced in the spice agony?

Odrade permits Duncan to watch Murbella undergo the spice agony, making him the first man ever to do so.

Not as great as the spice agony, though, she reminded herself.