Merotelic attachment occurs when one kinetochore is attached to both mitotic spindle poles.

Multipolar spindles: more than two spindle poles form.

Such a mitotic division would result in one daughter cell for each spindle pole; each cell may possess an unpredictable complement of chromosomes.

In early mitosis, it associates with mitotic spindle poles.

Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.

At the pointed ends, known as spindle poles, microtubules are nucleated by the centrosomes in most animal cells.

Most chromosome movements in relation to spindle poles are associated to lengthening and shortening of kMTs.

To achieve proper segregation, the two kinetochores on the sister chromatids must be attached to opposite spindle poles (bipolar orientation).

The chromatids are further separated by the physical movement of the spindle poles themselves.

Syntelic attachment occurs when both sister chromosomes are attached to a single spindle pole.