The idea of a device that doesn't need a needle or a syringe and the problems they cause would be a substantial advance.

These classes of vehicles will require substantial advances in technology.

By the standards of the time, there had been a substantial advance.

Fighting went on for two more weeks with no substantial advance by either side.

Only the supporting attack in the north achieved a substantial advance.

Contra negotiators, however, asserted that there had been no substantial advance.

The Woolf report represents a substantial advance upon the 'orthodox account'.

It was the first substantial advance in more than a dozen years of worldwide research.

First, the most substantial advances are in the area of justice and home affairs.

The substantial advances which it made on the earlier law were two: