The complete loss of the ship would be a substantial financial blow to anyone.

His mind has received the equivalent of a substantial physical blow.

This will be a substantial blow against women's reproductive freedom, a clear contradiction of Roe v. Wade, the 1973 decision legalizing abortion.

It would be a substantial blow, Killashandra had to admit, but not a patch on what Ballybran could brew.

Nonetheless, the loss of Thomas is a substantial blow that comes at a time when Memphis was finally starting to click.

For a college with about $60 million in annual spending needs, that was a substantial blow.

The huge losses on Wall Street constitute a substantial blow to the economy at large.

Analysts said Lockheed's losing the bulk of the rocket contracts in 1998 was a substantial blow to its space program.

Each side, particularly Gruner & Jahr, suffered substantial blows to its public image.

But the loss of the beasts was a substantial blow.