Indeed, substantial personal departures, and, in a few cases, contributions to a field, are seen.

Class B conditions are conditions that are identified as amounting to a substantial departure from normal well-being.

There is a substantial amount of controversy because this research suggests such a substantial departure from prior widely supported scientific consensus.

This season had, however, promised a more substantial departure in the theater's history.

Mr. Rowland's commitment to spend the additional money was a substantial departure from his initial budget proposal in February.

Do all those steaming pipes really add up to a substantial departure from modernism's machines for living?

I think Harris is a substantial departure.

Critics seemed to enjoy the game's creativity and unusual premise, as the game was a substantial departure from anything else on the market.

The program is a substantial departure for the Ford Foundation, which has traditionally made much smaller grants.

That appears to be a fairly substantial departure for you.