There must be a "substantial" impairment of mental responsibility.

Also, people in early stages of PTA have substantial impairment to anterograde memory function.

No laboratory monitoring is needed in patients receiving episodic or suppressive therapy unless the patient has substantial renal impairment.

It seems to me that this is a very substantial and serious impairment of Mr Frank's movements.

It exceeds normal "shyness" as it leads to excessive social avoidance and substantial social or occupational impairment.

Even acute alcohol intoxication (a blood alcohol concentration of 0.08-0.09%) produces a substantial impairment of working memory processes that require mnemonic rehearsal strategies.

Scores of 2 or greater suggests substantial cognitive impairment.

A: The ADA defines a disability as substantial impairment of a major life activity.

These include excessive fatigue that does not respond to bed rest,combined with four or more of the following symptoms: substantial impairment in short-term ...

The only exceptions would be to save a woman's life or to prevent "substantial and irreversible impairment of her major bodily functions."