Vivo-Morpholinos, in which the oligo is covalently linked to a delivery dendrimer, enter cells when administered systemically in adult animals.
In addition to therapy delivered directly to the brain and spinal fluid, systemically administered agents are also an important component of effective CNS prophylaxis.
Third, he said, the numbers of bacteria actually exposed to these agents are relatively small, compared with the targets of systemically administered antibiotics.
Several groups have failed to confirm the initially reported anabolic effect of systemically administered statins in vivo in rats [ 25 26 27 ] .
Strontium 89, a systemically administered radionuclide, can be administered for palliation of diffuse bony metastases.
It can be administered topically or systemically.
Drugs might also be administered systemically through injectable or oral formulations known as PrEP.
The cornerstone of this strategy includes systemically administered combination chemotherapy.
The mainstay of the therapeutic approach is systemically administered combination chemotherapy.