Opening day doesn't usually take on such significance for a player.

Once the basic strategy has been decided the timing of the offer takes on particular significance.

Any individual takes on significance only in his relationship to your total society.

In the next chapter these four points will take on greater significance.

But this simple action now took on much greater significance.

It was only later and by degrees that they had seemed to take on significance.

Women's issues and their reproductive rights took on great significance during the 2012 Presidential campaign.

After 28,000 miles perhaps winning or losing takes on less significance.

It is here that the words "I love you" take on significance.

The question of who pays for what can take on great significance.