Nephrotoxicity has also been observed with concentrations within the "therapeutic" range as well.
In addition to having a narrow therapeutic range, barbiturates are also addictive.
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"Her levels were double the normal therapeutic range."
Metabolism may become saturated (non-linear), even within the therapeutic range.
Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed.
Time within the therapeutic range was mean 62%.
The purpose was to establish the therapeutic range.
It exhibits greater antiepileptic properties than Levetiracetam but with a somewhat smaller, although still high, therapeutic range.
This, in turn, could produce drug plasma concentrations less than the desired therapeutic range.