If severe enough, blocked blood flow can cause tissue death.

This correlated the role of netrin with tissue death and growth.

If effective treatment is not started, tissue death and possible amputation usually follow quickly.

In addition, a badly swollen limb is subject to serious complications, from infection to tissue death.

Effects of the venom include severe pain, shock, paralysis, and tissue death.

There may be signs of tissue death or gangrene.

In severe cases, loss of blood flow can cause sores or tissue death.

This can help prevent tissue death and promote healing.

It requires immediate treatment to prevent tissue death and permanent dysfunction.

You have poor blood circulation leading to tissue death (gangrene).