This determines substrate specificity and is the site for interaction with TIMP's (tissue inhibitor of metalloproteinases).
Other gene markers of progression risk includes tissue inhibitor of metalloproteinase 3 (TIMP3), suggesting a role for intracellular matrix metabolism in AMD progression.
Balance in the MMP activity is usually achieved by tissue inhibitor of metalloproteinases (TIMP).
Their inhibitor, tissue inhibitor of metalloproteinase 1, was also found in the stroma but had a predominant endothelial distribution (N C Gallegos et al personal communication).
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.
This gene belongs to the tissue inhibitor of metalloproteinases gene family.
SST was found to increase matrix metalloproteinases activity with reduced tissue inhibitors of metalloproteinases activities on hepatic stellate cells possibly via P38 pathway (Sakaida et al., 2004).
Serum aliquots obtained at the initial visit were used for the analysis of serum MMP and tissue inhibitor of metalloproteinase (TIMP) levels.
The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs).