This area may also bleed and blister and can eventually lead to tissue necrosis.

Without immediate intervention, ischemia may progress quickly to tissue necrosis and gangrene within a few hours.

Early and massive tissue necrosis is a specific feature of Citrobacter koseri brain infection.

Other surgeons have reported tissue necrosis, in which the fat dies and must be removed.

Disadvantages include lack of margin control, tissue necrosis, over or under treatment of the tumor, and long recovery time.

In cases of tissue necrosis, surgical debridement and reconstruction may be necessary.

Sometimes plastic surgery and grafting is needed to deal with tissue necrosis.

In severe cases, the degree of complement fixation can be so substantial that it induces local tissue necrosis.

Pain will generally become more prominent as soft tissue necrosis becomes worse.

Risk for tissue necrosis is in part related to trauma or oral infection; however, idiopathic cases can also occur.