The ovaries of younger women can tolerate greater doses.
Patients who have a history of drug abuse may tolerate higher doses of medication to control pain.
Prepubertal females tolerate cumulative doses as high as 25 g/m2.
But Mr. Tools could not tolerate high enough doses to prevent clots.
But many others must be carefully adjusted for individuals, who often cannot tolerate certain products or doses.
Colony stimulating factors may help patients tolerate higher doses of chemotherapy.
More often the patient tolerates several - in one case 164 - doses before the fatal reaction occurs.
But many people cannot tolerate daily doses of the drug, which can cause allergic reactions and can damage the bone marrow.
However, some subjects could only tolerate single doses of 0.02 g/ day without experiencing side-effects.
The utility of radiation therapy is questioned because the liver cannot tolerate high doses of radiation.