Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain.

This is believed to be due to temperature-dependent precipitation of uric acid crystals in tissues at below normal temperature.

Gout is caused by deposition of uric acid crystals in the joint, causing inflammation.

In gout, uric acid crystals cause the cartilage to degenerate at a faster pace.

Colchicine blocks the inflammation caused by uric acid crystals.

Colchicine alters the way your body responds to uric acid crystals.

Pain and inflammation result from deposits of uric acid crystals in a joint or tendon.

By this time, enough uric acid crystals have accumulated in the body to form gritty nodules called tophi.

Your doctor may also take a sample of fluid from your joint to look for uric acid crystals.

Gout is essentially a disorder caused by precipitation of uric acid crystals in the joint.